Structural parameters of Zn(II) complexes of 8-hydroxyquinoline-based tripodal ligands affect fluorescence quantum yield

Maksim Royzen; James W. Canary

doi:10.1016/j.poly.2012.11.027

Structural parameters of Zn(II) complexes of 8-hydroxyquinoline-based tripodal ligands affect fluorescence quantum yield

Maksim Royzen, James W. Canary

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Tripodal ligands containing 8-hydroxyquinoline moieties have been reported with strong binding but perplexing fluorescence properties. Herein we describe the synthesis, photophysical properties and structural characterization of three 8-hydroxyquinoline-based fluorescent Zn(II) probes. Incorporation of the chromophore into a tripodal scaffold resulted in femtomolar sensitivity to the analyte. All three ligands were determined to bind Zn(II) in a 1:1 metal-ligand stoichiometry. Strong zinc affinity was complemented by more than 10-fold fluorescence turn-on. An X-ray crystallographic study revealed very different ligand geometries in the zinc complexes that may influence their spectroscopic behavior.

Original language	English (US)
Pages (from-to)	85-91
Number of pages	7
Journal	Polyhedron
Volume	58
DOIs	https://doi.org/10.1016/j.poly.2012.11.027
State	Published - 2013

Keywords

8-Hydroxyquinoline
Femtomolar sensitivity
Fluorescence
Tripodal ligand
X-ray structure
Zinc complex
Zinc sensor

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.poly.2012.11.027

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title = "Structural parameters of Zn(II) complexes of 8-hydroxyquinoline-based tripodal ligands affect fluorescence quantum yield",

abstract = "Tripodal ligands containing 8-hydroxyquinoline moieties have been reported with strong binding but perplexing fluorescence properties. Herein we describe the synthesis, photophysical properties and structural characterization of three 8-hydroxyquinoline-based fluorescent Zn(II) probes. Incorporation of the chromophore into a tripodal scaffold resulted in femtomolar sensitivity to the analyte. All three ligands were determined to bind Zn(II) in a 1:1 metal-ligand stoichiometry. Strong zinc affinity was complemented by more than 10-fold fluorescence turn-on. An X-ray crystallographic study revealed very different ligand geometries in the zinc complexes that may influence their spectroscopic behavior.",

keywords = "8-Hydroxyquinoline, Femtomolar sensitivity, Fluorescence, Tripodal ligand, X-ray structure, Zinc complex, Zinc sensor",

author = "Maksim Royzen and Canary, {James W.}",

note = "Funding Information: This work was supported by the National Institutes of Health ( GM076202 ) and the National Science Foundation ( CHE-0848234 ). Special thanks for crystallographic work to William W. Brennessel and Victor G. Young, Jr. of the X-Ray Crystallographic Laboratory, Department of Chemistry, University of Minnesota. ",

year = "2013",

doi = "10.1016/j.poly.2012.11.027",

language = "English (US)",

volume = "58",

pages = "85--91",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Structural parameters of Zn(II) complexes of 8-hydroxyquinoline-based tripodal ligands affect fluorescence quantum yield

AU - Royzen, Maksim

AU - Canary, James W.

N1 - Funding Information: This work was supported by the National Institutes of Health ( GM076202 ) and the National Science Foundation ( CHE-0848234 ). Special thanks for crystallographic work to William W. Brennessel and Victor G. Young, Jr. of the X-Ray Crystallographic Laboratory, Department of Chemistry, University of Minnesota.

PY - 2013

Y1 - 2013

N2 - Tripodal ligands containing 8-hydroxyquinoline moieties have been reported with strong binding but perplexing fluorescence properties. Herein we describe the synthesis, photophysical properties and structural characterization of three 8-hydroxyquinoline-based fluorescent Zn(II) probes. Incorporation of the chromophore into a tripodal scaffold resulted in femtomolar sensitivity to the analyte. All three ligands were determined to bind Zn(II) in a 1:1 metal-ligand stoichiometry. Strong zinc affinity was complemented by more than 10-fold fluorescence turn-on. An X-ray crystallographic study revealed very different ligand geometries in the zinc complexes that may influence their spectroscopic behavior.

AB - Tripodal ligands containing 8-hydroxyquinoline moieties have been reported with strong binding but perplexing fluorescence properties. Herein we describe the synthesis, photophysical properties and structural characterization of three 8-hydroxyquinoline-based fluorescent Zn(II) probes. Incorporation of the chromophore into a tripodal scaffold resulted in femtomolar sensitivity to the analyte. All three ligands were determined to bind Zn(II) in a 1:1 metal-ligand stoichiometry. Strong zinc affinity was complemented by more than 10-fold fluorescence turn-on. An X-ray crystallographic study revealed very different ligand geometries in the zinc complexes that may influence their spectroscopic behavior.

KW - 8-Hydroxyquinoline

KW - Femtomolar sensitivity

KW - Fluorescence

KW - Tripodal ligand

KW - X-ray structure

KW - Zinc complex

KW - Zinc sensor

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U2 - 10.1016/j.poly.2012.11.027

DO - 10.1016/j.poly.2012.11.027

M3 - Article

AN - SCOPUS:84880149152

SN - 0277-5387

VL - 58

SP - 85

EP - 91

JO - Polyhedron

JF - Polyhedron

ER -

Structural parameters of Zn(II) complexes of 8-hydroxyquinoline-based tripodal ligands affect fluorescence quantum yield

Abstract

Keywords

ASJC Scopus subject areas

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