Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Matthew P. Glenn; Sung Youn Chang; Oliver Hucke; Christophe L.M.J. Verlinde; Kasey Rivas; Carrie Hornéy; Kohei Yokoyama; Frederick S. Buckner; Prakash R. Pendyala; Debopam Chakrabarti; Michael Gelb; Wesley C. Van Voorhis; Saïd M. Sebti; Andrew D. Hamilton

doi:10.1002/anie.200500674

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Matthew P. Glenn, Sung Youn Chang, Oliver Hucke, Christophe L.M.J. Verlinde, Kasey Rivas, Carrie Hornéy, Kohei Yokoyama, Frederick S. Buckner, Prakash R. Pendyala, Debopam Chakrabarti, Michael Gelb, Wesley C. Van Voorhis, Saïd M. Sebti, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Antimalarial compounds: Structurally simple acyclic inhibitors of protein farnesyltransferase (active-site model shown) from the malaria parasite Plasmodium falciparum may allow third world countries access to an effective and inexpensive antimalarial therapy to counter the estimated half billion infections that occur annually.

Original language	English (US)
Pages (from-to)	4903-4906
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	31
DOIs	https://doi.org/10.1002/anie.200500674
State	Published - Aug 5 2005

Keywords

Design
Drug
Enzymes
Inhibitors
Malaria
Medicinal chemistry

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200500674

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Glenn, M. P., Chang, S. Y., Hucke, O., Verlinde, C. L. M. J., Rivas, K., Hornéy, C., Yokoyama, K., Buckner, F. S., Pendyala, P. R., Chakrabarti, D., Gelb, M., Van Voorhis, W. C., Sebti, S. M., & Hamilton, A. D. (2005). Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angewandte Chemie - International Edition, 44(31), 4903-4906. https://doi.org/10.1002/anie.200500674

Glenn, MP, Chang, SY, Hucke, O, Verlinde, CLMJ, Rivas, K, Hornéy, C, Yokoyama, K, Buckner, FS, Pendyala, PR, Chakrabarti, D, Gelb, M, Van Voorhis, WC, Sebti, SM & Hamilton, AD 2005, 'Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites', Angewandte Chemie - International Edition, vol. 44, no. 31, pp. 4903-4906. https://doi.org/10.1002/anie.200500674

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AU - Hornéy, Carrie

AU - Yokoyama, Kohei

AU - Buckner, Frederick S.

AU - Pendyala, Prakash R.

AU - Chakrabarti, Debopam

AU - Gelb, Michael

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Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Abstract

Keywords

ASJC Scopus subject areas

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