Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

Matthew P. Glenn, Sung Youn Chang, Oliver Hucke, Christophe L.M.J. Verlinde, Kasey Rivas, Carrie Hornéy, Kohei Yokoyama, Frederick S. Buckner, Prakash R. Pendyala, Debopam Chakrabarti, Michael Gelb, Wesley C. Van Voorhis, Saïd M. Sebti, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Antimalarial compounds: Structurally simple acyclic inhibitors of protein farnesyltransferase (active-site model shown) from the malaria parasite Plasmodium falciparum may allow third world countries access to an effective and inexpensive antimalarial therapy to counter the estimated half billion infections that occur annually.

Original languageEnglish (US)
Pages (from-to)4903-4906
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number31
DOIs
StatePublished - Aug 5 2005

Keywords

  • Design
  • Drug
  • Enzymes
  • Inhibitors
  • Malaria
  • Medicinal chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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