Structure and antimicrobial properties of multivalent short peptides

Anne W. Young, Zhigang Liu, Chunhui Zhou, Filbert Totsingan, Nikhil Jiwrajka, Zhengshuang Shi, Neville R. Kallenbach

Research output: Contribution to journalArticle

Abstract

The emergence of multidrug-resistant (MDR) strains continues to threaten human health. Along with many efforts directed towards the development of antimicrobial peptides (AMPs) as potential antibiotics, we have designed and tested several series of multivalent AMPs in comparison with the natural AMP, indolicidin. Constructs include multivalent displays with different sequences, repeats and scaffolds, including dendrimers, brush-like structures and polymeric displays constructed by linking various peptides to polymaleic anhydride (PMA). A branched tetramer of dipeptides (RW)4D demonstrates the highest level of effectiveness among the constructs of this study. The results also show that under extended exposure to sublethal doses of (RW)4D and indolicidin over a 400 generations period, MDR strains elicit much lower levels of resistance than to traditional antibiotics or disinfectants such as ciprofloxacin, vancomycin, chlorhexidine and gentamicin.

Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalMedChemComm
Volume2
Issue number4
DOIs
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Young, A. W., Liu, Z., Zhou, C., Totsingan, F., Jiwrajka, N., Shi, Z., & Kallenbach, N. R. (2011). Structure and antimicrobial properties of multivalent short peptides. MedChemComm, 2(4), 308-314. https://doi.org/10.1039/c0md00247j