Structure, function and evolution of multidomain proteins

Christine Vogel, Matthew Bashton, Nicola D. Kerrison, Cyrus Chothia, Sarah A. Teichmann

Research output: Contribution to journalReview articlepeer-review


Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
JournalCurrent Opinion in Structural Biology
Issue number2
StatePublished - Apr 2004


  • PDB
  • Protein Data Bank
  • RMSD
  • Root mean square deviation
  • SCOP
  • SH
  • Src homology
  • Structural Classification of Proteins
  • WHD
  • Winged helix domain

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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