Studies on the conformation and dynamics of the C8-substituted guanlne adduct of the carcinogen acetytaminofluorene; model for a possible Z-DNA modified structure

Stephen Neidle, Reiko Kuroda, Suse Broyde, Brian E. Hingerty, Robert A. Levine, Dwight W. Miller, Frederick E. Evans

Research output: Contribution to journalArticlepeer-review

Abstract

The structure of an adduct between guanine and the carcinogen acetylaminofluorene has been examined in the solid state by X-ray crystallography, and in solution by NMR techniques. The observed conformations have been compared with predictions from energy calculations and their relevance to models of adducts with DNA has been examined.

Original languageEnglish (US)
Pages (from-to)8219-8233
Number of pages15
JournalNucleic acids research
Volume12
Issue number21
DOIs
StatePublished - Nov 12 1984

ASJC Scopus subject areas

  • Genetics

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