The C1-C15 spiroquinolizidine subunit (cf. 2) of the marine natural product halichlorine (1) was prepared in 12 steps starting from the known 'Meyers-lactam' 5. The synthesis involves a B-alkyl-Suzuki coupling followed by a highly stereoselective intramolecular Michael addition and an intramolecular Mannich ring closure.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 3 1999|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry