Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women

Jeffrey B. Payne, Julie A. Stoner, Pirkka V. Nummikoski, Richard A. Reinhardt, Arthur D. Goren, Mark S. Wolff, Hsi Ming Lee, James C. Lynch, Robert Valente, Lorne M. Golub

Research output: Contribution to journalArticlepeer-review


Aim: Determine the efficacy of 2-year continuous subantimicrobial dose doxycycline (SDD; 20 mg bid) on alveolar bone in post-menopausal osteopenic, oestrogen-deficient women undergoing periodontal maintenance in a 2-year double-blind, placebo-controlled, randomized clinical trial. Material and Methods: One-hundred and twenty-eight subjects randomized to SDD or placebo (n=64 each). Posterior vertical bite wings taken at baseline, 1 and 2 years for alveolar bone density (ABD), using radiographic absorptiometry (RA) and computer-assisted densitometric image analysis (CADIA), and alveolar bone height (ABH). Statistical analyses utilized generalized estimating equations; primary analyses were intent to treat (ITT). Results are presented as SDD versus placebo. Results: Under ITT, there was no statistically significant effect of SDD on ABD loss (RA: p=0.8; CADIA: p=0.2) or ABH loss (p=0.2). Most sites (81-95%) were inactive. For subgroup analyses, mean CADIA was higher with SDD for non-smokers (p=0.05) and baseline probing depths ≥5 mm (p=0.003). SDD was associated with 29% lower odds of more progressive ABH loss in women >5 years post-menopausal (p=0.05) and 36% lower among protocol-adherent subjects (p=0.03). Conclusions: In post-menopausal osteopenic women with periodontitis, SDD did not differ overall from placebo. Based on exploratory subgroup analyses, additional research is needed to determine the usefulness of SDD in non-smokers, subjects >5 years post-menopausal and in deeper pockets.Protocol registered at Identifier: NCT00066027

Original languageEnglish (US)
Pages (from-to)776-787
Number of pages12
JournalJournal of clinical periodontology
Issue number9
StatePublished - Sep 2007


  • Computer-assisted densitometric image analysis (CADIA)
  • Dual-energy X-ray absorptiometry (DEXA)
  • Osteopenia
  • Periodontal maintenance
  • Periodontitis
  • Post-menopausal
  • Radiographic absorptiometry (RA) method
  • Randomized clinical trial

ASJC Scopus subject areas

  • Periodontics


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