Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

Andrew F. MacAskill, Justin P. Little, John M. Cassel, Adam G. Carter

Research output: Contribution to journalArticlepeer-review

Abstract

We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.

Original languageEnglish (US)
Pages (from-to)1624-1626
Number of pages3
JournalNature Neuroscience
Volume15
Issue number12
DOIs
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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