Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

Andrew F. MacAskill; Justin P. Little; John M. Cassel; Adam G. Carter

doi:10.1038/nn.3254

Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

Andrew F. MacAskill, Justin P. Little, John M. Cassel, Adam G. Carter

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.

Original language	English (US)
Pages (from-to)	1624-1626
Number of pages	3
Journal	Nature Neuroscience
Volume	15
Issue number	12
DOIs	https://doi.org/10.1038/nn.3254
State	Published - Dec 2012

ASJC Scopus subject areas

General Neuroscience

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title = "Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens",

abstract = "We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.",

author = "MacAskill, {Andrew F.} and Little, {Justin P.} and Cassel, {John M.} and Carter, {Adam G.}",

note = "Funding Information: We thank members of the Carter laboratory, M. Farrant, B. Sabatini and R. Tsien for helpful discussions and comments on the manuscript. This work was supported by the Whitehall Foundation, Dana Foundation and McKnight Foundation (A.G.C.). A.F.M. is a Sir Henry Wellcome Postdoctoral Fellow.",

year = "2012",

month = dec,

doi = "10.1038/nn.3254",

language = "English (US)",

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journal = "Nature Neuroscience",

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AU - Little, Justin P.

AU - Cassel, John M.

AU - Carter, Adam G.

N1 - Funding Information: We thank members of the Carter laboratory, M. Farrant, B. Sabatini and R. Tsien for helpful discussions and comments on the manuscript. This work was supported by the Whitehall Foundation, Dana Foundation and McKnight Foundation (A.G.C.). A.F.M. is a Sir Henry Wellcome Postdoctoral Fellow.

PY - 2012/12

Y1 - 2012/12

N2 - We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.

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Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens

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