Abstract
A method to synthesize thioethers and thioesters directly from readily available sulfonyl chlorides is reported. We demonstrate that a transient intermediate formed during phosphine-mediated deoxygenation of sulfonyl chlorides can be trapped in situ by activated alcohols or carboxylic acids to effect carbon-sulfur bond formation. The method is operationally simple and tolerates a broad range of functional groups. Special attention has been focused on the late-stage diversification of densely functionalized natural products and pharmaceuticals.
Original language | English (US) |
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Pages (from-to) | 6454-6458 |
Number of pages | 5 |
Journal | Journal of Organic Chemistry |
Volume | 87 |
Issue number | 9 |
DOIs | |
State | Published - May 6 2022 |
ASJC Scopus subject areas
- Organic Chemistry