13C NMR spectroscopy for the quantitative determination of compound ratios and polymer end groups

Douglas A.L. Otte, Dorothee E. Borchmann, Chin Lin, Marcus Weck, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

13C NMR spectroscopic integration employing short relaxation delays was evaluated as a quantitative tool to obtain ratios of diastereomers, regioisomers, constitutional isomers, mixtures of unrelated compounds, peptoids, and sugars. The results were compared to established quantitative methods such as 1H NMR spectroscopic integration, gas chromatography, and high-performance liquid chromatography and were found to be within <3.4% of 1H NMR spectroscopic values (most examples give results within <2%). Acquisition of the spectra took 2-30 min on as little as 10 mg of sample, proving the general utility of the technique. The simple protocol was extended to include end group analysis of low molecular weight polymers, which afforded results in accordance with 1H NMR spectroscopy and matrix-assisted laser desorption-ionization time-of-flight spectrometry.

Original languageEnglish (US)
Pages (from-to)1566-1569
Number of pages4
JournalOrganic Letters
Volume16
Issue number6
DOIs
StatePublished - Mar 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of '<sup>13</sup>C NMR spectroscopy for the quantitative determination of compound ratios and polymer end groups'. Together they form a unique fingerprint.

  • Cite this