Super-resolution Optical Coherence Tomography for Biomedical Applications

Pauline John, Azhar Zam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical coherence tomography (OCT) is a non-invasive, label-free, depth-resolved imaging and diagnostic technique with eclectic applications in medical and industrial domains. The typical resolution of structural changes detected by conventional depth-resolved OCT technique is about 1 to 15 µm. Detection of nanoscale structural changes of biological tissues, aids in functional imaging of pathological processes which is not possible to detect using conventional intensity based OCT technique. The detection of biological tissues in nanoscale order is addressed in this work, using a SLED source of centre wavelength 930 nm, a bandwidth of 102 nm and a wavelength range of 874 nm to 1027 nm. This method helps in retaining high spatial frequency information and visualizing the structural changes occurring in biological tissues with spatial periods between 291 nm to 343 nm, without the need for excision as in the case of histological examination of morphological changes in the ultra-structures of biological tissues. A difference of 5 to 10 nm in the spatial periods of biological structures were clearly observed from the nanosensitive OCT (nsOCT) results of in vivo nail and finger tissues.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII
EditorsJoseph A. Izatt, James G. Fujimoto
PublisherSPIE
ISBN (Electronic)9781510669192
DOIs
StatePublished - 2024
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII 2024 - San Francisco, United States
Duration: Jan 29 2024Jan 31 2024

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12830
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII 2024
Country/TerritoryUnited States
CitySan Francisco
Period1/29/241/31/24

Keywords

  • biomedical applications
  • nail diseases
  • Nanosensitive
  • optical coherence tomography
  • super-resolution

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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