Super-secondary structure peptidomimetics: Design and synthesis of an α-α hairpin analogue

Laura Nevola, Johanna M. Rodriguez, Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

The α-α helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein, we describe the design, synthesis and structural characterisation of an α-α hairpin analogue based on a tetra-coordinated Pd(II) bis-(iminoisoquinoline) complex as a template for the display of two α-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side chains of the i and i+4 residues of two helices.

Original languageEnglish (US)
Pages (from-to)586-590
Number of pages5
JournalSupramolecular Chemistry
Volume25
Issue number9-11
DOIs
StatePublished - Sep 18 2013

Keywords

  • GCN4
  • alpha helix
  • protein - protein interaction
  • side chain
  • structural mimicry

ASJC Scopus subject areas

  • Chemistry(all)

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