Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Lishomwa C. Ndhlovu; Joan M. Chapman; Aashish R. Jha; Jennifer E. Snyder-Cappione; Moraima Pagán; Fabio E. Leal; Brigid S. Boland; Philip J. Norris; Michael G. Rosenberg; Douglas F. Nixon

doi:10.1097/QAD.0b013e3282ff884e

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Lishomwa C. Ndhlovu, Joan M. Chapman, Aashish R. Jha, Jennifer E. Snyder-Cappione, Moraima Pagán, Fabio E. Leal, Brigid S. Boland, Philip J. Norris, Michael G. Rosenberg, Douglas F. Nixon

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

Original language	English (US)
Pages (from-to)	990-992
Number of pages	3
Journal	AIDS
Volume	22
Issue number	8
DOIs	https://doi.org/10.1097/QAD.0b013e3282ff884e
State	Published - May 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0b013e3282ff884e

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title = "Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection",

abstract = "IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.",

author = "Ndhlovu, {Lishomwa C.} and Chapman, {Joan M.} and Jha, {Aashish R.} and Snyder-Cappione, {Jennifer E.} and Moraima Pag{\'a}n and Leal, {Fabio E.} and Boland, {Brigid S.} and Norris, {Philip J.} and Rosenberg, {Michael G.} and Nixon, {Douglas F.}",

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T1 - Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

AU - Ndhlovu, Lishomwa C.

AU - Chapman, Joan M.

AU - Jha, Aashish R.

AU - Snyder-Cappione, Jennifer E.

AU - Pagán, Moraima

AU - Leal, Fabio E.

AU - Boland, Brigid S.

AU - Norris, Philip J.

AU - Rosenberg, Michael G.

AU - Nixon, Douglas F.

PY - 2008/5

Y1 - 2008/5

N2 - IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

AB - IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

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Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Abstract

ASJC Scopus subject areas

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