Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Lishomwa C. Ndhlovu, Joan M. Chapman, Aashish R. Jha, Jennifer E. Snyder-Cappione, Moraima Pagán, Fabio E. Leal, Brigid S. Boland, Philip J. Norris, Michael G. Rosenberg, Douglas F. Nixon

Research output: Contribution to journalArticlepeer-review

Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

Original languageEnglish (US)
Pages (from-to)990-992
Number of pages3
JournalAIDS
Volume22
Issue number8
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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