Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Lishomwa C. Ndhlovu; Joan M. Chapman; Aashish R. Jha; Jennifer E. Snyder-Cappione; Moraima Pagán; Fabio E. Leal; Brigid S. Boland; Philip J. Norris; Michael G. Rosenberg; Douglas F. Nixon

doi:10.1097/QAD.0b013e3282ff884e

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Lishomwa C. Ndhlovu, Joan M. Chapman, Aashish R. Jha, Jennifer E. Snyder-Cappione, Moraima Pagán, Fabio E. Leal, Brigid S. Boland, Philip J. Norris, Michael G. Rosenberg, Douglas F. Nixon

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

Original language	English (US)
Pages (from-to)	990-992
Number of pages	3
Journal	AIDS
Volume	22
Issue number	8
DOIs	https://doi.org/10.1097/QAD.0b013e3282ff884e
State	Published - May 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0b013e3282ff884e

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Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. / Ndhlovu, Lishomwa C.; Chapman, Joan M.; Jha, Aashish R.; Snyder-Cappione, Jennifer E.; Pagán, Moraima; Leal, Fabio E.; Boland, Brigid S.; Norris, Philip J.; Rosenberg, Michael G.; Nixon, Douglas F.

In: AIDS, Vol. 22, No. 8, 05.2008, p. 990-992.

Research output: Contribution to journal › Article › peer-review

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title = "Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection",

abstract = "IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.",

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AU - Ndhlovu, Lishomwa C.

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AU - Snyder-Cappione, Jennifer E.

AU - Pagán, Moraima

AU - Leal, Fabio E.

AU - Boland, Brigid S.

AU - Norris, Philip J.

AU - Rosenberg, Michael G.

AU - Nixon, Douglas F.

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AB - IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

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Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Abstract

ASJC Scopus subject areas

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