Supramolecular dendrimers: Convenient synthesis by programmed self-assembly and tunable thermoresponsivity

Partha S. Ghosh, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

We report here the noncovalent synthesis of thermosensitive dendrimers. Short oligoguanosine strands were linked to the focal point of a dendron by using "click chemistry", and quadruplex formation was used to drive the self-assembly process in the presence of metal ions. The dynamic nature of these noncovalent assemblies can be exploited to create combinatorial libraries of dendrimers as demonstrated by the co-assembly of two components. These supramolecular dendrimers showed thermoresponsive behavior that can be tuned by varying the templating cations or the number of guanines in the oligonucleotide strand.

Original languageEnglish (US)
Pages (from-to)2361-2365
Number of pages5
JournalChemistry - A European Journal
Volume18
Issue number8
DOIs
StatePublished - Feb 20 2012

Keywords

  • click chemistry
  • self-assembly
  • stimuli-responsive
  • supramolecular dendrimers

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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