Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+T-cells promotes their mechanotransduction and activation

Rui Li; Walida Ali; Chao Ma; Apratim Bajpai; Ngoc Luu; Aarushi Varshney; Camden Riley Rowe; Weiqiang Chen

doi:10.1039/d1cc05194f

Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8⁺T-cells promotes their mechanotransduction and activation

Rui Li, Walida Ali, Chao Ma, Apratim Bajpai, Ngoc Luu, Aarushi Varshney, Camden Riley Rowe, Weiqiang Chen

Research output: Contribution to journal › Article › peer-review

Abstract

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

Original language	English (US)
Pages (from-to)	12667-12670
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	94
DOIs	https://doi.org/10.1039/d1cc05194f
State	Published - Dec 7 2021

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d1cc05194f

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title = "Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+T-cells promotes their mechanotransduction and activation",

abstract = "We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.",

author = "Rui Li and Walida Ali and Chao Ma and Apratim Bajpai and Ngoc Luu and Aarushi Varshney and Rowe, {Camden Riley} and Weiqiang Chen",

note = "Funding Information: This work was supported by the National Institutes of Health (R35GM133646). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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T1 - Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+T-cells promotes their mechanotransduction and activation

AU - Li, Rui

AU - Ali, Walida

AU - Ma, Chao

AU - Bajpai, Apratim

AU - Luu, Ngoc

AU - Varshney, Aarushi

AU - Rowe, Camden Riley

AU - Chen, Weiqiang

N1 - Funding Information: This work was supported by the National Institutes of Health (R35GM133646). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/12/7

Y1 - 2021/12/7

N2 - We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

AB - We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

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U2 - 10.1039/d1cc05194f

DO - 10.1039/d1cc05194f

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 94

ER -

Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8⁺T-cells promotes their mechanotransduction and activation

Abstract

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