Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+T-cells promotes their mechanotransduction and activation

Rui Li, Walida Ali, Chao Ma, Apratim Bajpai, Ngoc Luu, Aarushi Varshney, Camden Riley Rowe, Weiqiang Chen

Research output: Contribution to journalArticlepeer-review

Abstract

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

Original languageEnglish (US)
Pages (from-to)12667-12670
Number of pages4
JournalChemical Communications
Volume57
Issue number94
DOIs
StatePublished - Dec 7 2021

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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