Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+T-cells promotes their mechanotransduction and activation

Rui Li, Walida Ali, Chao Ma, Apratim Bajpai, Ngoc Luu, Aarushi Varshney, Camden Riley Rowe, Weiqiang Chen

Research output: Contribution to journalArticlepeer-review

Abstract

We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8+ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

Original languageEnglish (US)
Pages (from-to)12667-12670
Number of pages4
JournalChemical Communications
Volume57
Issue number94
DOIs
StatePublished - Dec 7 2021

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

Fingerprint

Dive into the research topics of 'Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8+T-cells promotes their mechanotransduction and activation'. Together they form a unique fingerprint.

Cite this