TY - JOUR
T1 - Swirling Instability of the Microtubule Cytoskeleton
AU - Stein, David B.
AU - De Canio, Gabriele
AU - Lauga, Eric
AU - Shelley, Michael J.
AU - Goldstein, Raymond E.
N1 - Funding Information:
We are indebted to Maik Drechsler and Isabel Palacios for sharing the data in Fig. and to Vladimir Gelfand, Daniel St Johnston, and Stanislav Shvartsman for discussions on Drosophila streaming. This work was supported in part by ERC Consolidator Grant No. 682754 (E. L.), Wellcome Trust Investigator Grant No. 207510/Z/17/Z, Established Career Fellowship EP/M017982/1 from the Engineering and Physical Sciences Research Council, and the Schlumberger Chair Fund (R. E. G.). M. J. S. acknowledges the support of NSF Grant No. DMS-1620331.
Publisher Copyright:
© 2021 authors. Published by the American Physical Society.
PY - 2021/1/13
Y1 - 2021/1/13
N2 - In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long microtubules, as are the collective fluid flows generated by many moving motors. Studies of streaming during oocyte development in the fruit fly Drosophila melanogaster have shown a transition from a spatially disordered cytoskeleton, supporting flows with onlyshort-ranged correlations, to an ordered state with a cell-spanning vortical flow. To test the hypothesis that this transition is driven by fluid-structure interactions, we study a discrete-filamentmodel and a coarse-grained continuum theory for motors moving on a deformable cytoskeleton, both ofwhich are shown to exhibit a swirling instability to spontaneous large-scale rotational motion, as observed.
AB - In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long microtubules, as are the collective fluid flows generated by many moving motors. Studies of streaming during oocyte development in the fruit fly Drosophila melanogaster have shown a transition from a spatially disordered cytoskeleton, supporting flows with onlyshort-ranged correlations, to an ordered state with a cell-spanning vortical flow. To test the hypothesis that this transition is driven by fluid-structure interactions, we study a discrete-filamentmodel and a coarse-grained continuum theory for motors moving on a deformable cytoskeleton, both ofwhich are shown to exhibit a swirling instability to spontaneous large-scale rotational motion, as observed.
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U2 - 10.1103/PhysRevLett.126.028103
DO - 10.1103/PhysRevLett.126.028103
M3 - Article
C2 - 33512217
AN - SCOPUS:85099935810
SN - 0031-9007
VL - 126
JO - Physical Review Letters
JF - Physical Review Letters
IS - 2
M1 - 028103
ER -