Switching Gears: Translational Mastery of Transcription during Memory Formation

Charles A. Hoeffer; Eric Klann

doi:10.1016/j.neuron.2007.04.003

Switching Gears: Translational Mastery of Transcription during Memory Formation

Charles A. Hoeffer, Eric Klann

Neural Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2α.

Original language	English (US)
Pages (from-to)	186-189
Number of pages	4
Journal	Neuron
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2007.04.003
State	Published - Apr 19 2007

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2007.04.003

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title = "Switching Gears: Translational Mastery of Transcription during Memory Formation",

abstract = "A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the {"}neural decision{"} to undergo these persistent neuronal changes under translational control mediated by eIF2α.",

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AU - Klann, Eric

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AB - A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2α.

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Switching Gears: Translational Mastery of Transcription during Memory Formation

Abstract

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