Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala

Valérie Doyère, Jacek Dȩbiec, Marie H. Monfils, Glenn E. Schafe, Joseph E. LeDoux

Research output: Contribution to journalArticlepeer-review

Abstract

When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.

Original languageEnglish (US)
Pages (from-to)414-416
Number of pages3
JournalNature Neuroscience
Volume10
Issue number4
DOIs
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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