Synaptic amplification by active membrane in dendritic spines

J. P. Miller, W. Rall, J. Rinzel

Research output: Contribution to journalArticlepeer-review


The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem resistance) show that an active spine head membrane can provide very significant synaptic amplification and also strongly non-linear properties that could modulate the integration of input from many afferent sources.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalBrain Research
Issue number1-2
StatePublished - Jan 28 1985


  • dendritic spines
  • excitatory postsynaptic potential computations
  • plasticity
  • spine-stem-resistance
  • synaptic amplification
  • synaptic efficacy

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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