Synaptic amplification by active membrane in dendritic spines

J. P. Miller; W. Rall; J. Rinzel

doi:10.1016/0006-8993(85)90333-6

Synaptic amplification by active membrane in dendritic spines

J. P. Miller, W. Rall, J. Rinzel

Research output: Contribution to journal › Article › peer-review

Abstract

The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem resistance) show that an active spine head membrane can provide very significant synaptic amplification and also strongly non-linear properties that could modulate the integration of input from many afferent sources.

Original language	English (US)
Pages (from-to)	325-330
Number of pages	6
Journal	Brain Research
Volume	325
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)90333-6
State	Published - Jan 28 1985

Keywords

dendritic spines
excitatory postsynaptic potential computations
plasticity
spine-stem-resistance
synaptic amplification
synaptic efficacy

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)90333-6

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title = "Synaptic amplification by active membrane in dendritic spines",

abstract = "The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem resistance) show that an active spine head membrane can provide very significant synaptic amplification and also strongly non-linear properties that could modulate the integration of input from many afferent sources.",

keywords = "dendritic spines, excitatory postsynaptic potential computations, plasticity, spine-stem-resistance, synaptic amplification, synaptic efficacy",

author = "Miller, {J. P.} and W. Rall and J. Rinzel",

note = "Funding Information: We thank Barry Bunow for assistancwe ith development of computer programs, Idan Segev and Gwen Jacobs for valuabled iscussionT. his work was supportedin part by NSF Grant BNS-8202416a nd a Sloan Foundation Fellowship, both awarded to J.P.M.",

year = "1985",

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day = "28",

doi = "10.1016/0006-8993(85)90333-6",

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T1 - Synaptic amplification by active membrane in dendritic spines

AU - Miller, J. P.

AU - Rall, W.

AU - Rinzel, J.

N1 - Funding Information: We thank Barry Bunow for assistancwe ith development of computer programs, Idan Segev and Gwen Jacobs for valuabled iscussionT. his work was supportedin part by NSF Grant BNS-8202416a nd a Sloan Foundation Fellowship, both awarded to J.P.M.

PY - 1985/1/28

Y1 - 1985/1/28

N2 - The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem resistance) show that an active spine head membrane can provide very significant synaptic amplification and also strongly non-linear properties that could modulate the integration of input from many afferent sources.

AB - The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem resistance) show that an active spine head membrane can provide very significant synaptic amplification and also strongly non-linear properties that could modulate the integration of input from many afferent sources.

KW - dendritic spines

KW - excitatory postsynaptic potential computations

KW - plasticity

KW - spine-stem-resistance

KW - synaptic amplification

KW - synaptic efficacy

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JO - Brain Research

JF - Brain Research

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ER -

Synaptic amplification by active membrane in dendritic spines

Abstract

Keywords

ASJC Scopus subject areas

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