Synaptic reverberation underlying mnemonic persistent activity

Research output: Contribution to journalReview articlepeer-review


Stimulus-specific persistent neural activity is the neural process underlying active (working) memory. Since its discovery 30 years ago, mnemonic activity has been hypothesized to be sustained by synaptic reverberation in a recurrent circuit. Recently, experimental and modeling work has begun to test the reverberation hypothesis at the cellular level. Moreover, theory has been developed to describe memory storage of an analog stimulus (such as spatial location or eye position), in terms of continuous 'bump attractors' and 'line attractors'. This review summarizes new studies, and discusses insights and predictions from biophysically based models. The stability of a working memory network is recognized as a serious problem; stability can be achieved if reverberation is largely mediated by NMDA receptors at recurrent synapses.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalTrends in Neurosciences
Issue number8
StatePublished - Aug 1 2001

ASJC Scopus subject areas

  • General Neuroscience


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