Syndecan-3: A cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis

Maurizio Pacifici, Tsuyoshi Shimo, Chiara Gentili, Thorsten Kirsch, Theresa A. Freeman, Motomi Enomoto-Iwamoto, Masahiro Iwamoto, Eiki Koyama

    Research output: Contribution to journalReview article

    Abstract

    Syndecans are single-pass integral membrane components that serve as co-receptors for growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We review here previous studies from our groups on syndecan-3 biology and function in the growth plates of developing long bones in chick and mouse embryos. Gain- and loss-of-function data indicate that syndecan-3 has important roles in restricting mitotic activity to the proliferative zone of growth plate and may do so in close cooperation and interaction with the signaling molecule Indian hedgehog (IHH). Biochemical and protein-modeling data suggest a dimeric/oligomeric syndecan-3 configuration on the chondrocyte's cell surface. Analyses of embryos misexpressing syndecan-3 or lacking IHH provide further clues on syndecan-3/IHH interdependence and interrelationships. The data and the conclusions reached provide insights into mechanisms fine-tuning chondrocyte proliferation, maturation, and function in the developing and growing skeleton and into how abnormalities in these fundamental mechanisms may subtend human congenital pathologies, including osteochondromas in hereditary multiple exostoses syndrome.

    Original languageEnglish (US)
    Pages (from-to)191-199
    Number of pages9
    JournalJournal of Bone and Mineral Metabolism
    Volume23
    Issue number3
    DOIs
    StatePublished - May 2005

    Keywords

    • Chondrocyte maturation
    • Chondrocyte proliferation
    • Growth plate
    • Indian hedgehog
    • Limb skeletogenesis
    • Syndecan-3

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Orthopedics and Sports Medicine
    • Endocrinology

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