TY - JOUR
T1 - Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse
AU - Gerig, Guido
AU - Oguz, Ipek
AU - Gouttard, Sylvain
AU - Lee, Joohwi
AU - An, Hongyu
AU - Lin, Weili
AU - McMurray, Matthew
AU - Grewen, Karen
AU - Johns, Josephine
AU - Styner, Martin Andreas
N1 - Funding Information:
Funding: This research was supported by the National Science Foundation (#0729063 and #1019303). DG was supported by a post-doctoral fellowship from the National Socio-Environmental Synthesis Center (SESYNC) under funding from the National Science Foundation (DBI-1052875). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
This research was supported by the National Science Foundation (#0729063 and #1019303). DG was supported by a post-doctoral fellowship from the National Socio-Environmental Synthesis Center (SESYNC) under funding from the National Science Foundation (DBI-1052875). We wish to thank the people in Kamchatka who participated in our research, as well as Dr. Viktoria Petrasheva, and Tatiana Degai for research and field assistance. We also thank Cris-tina Gaina Blanton who assisted in the field experiments and Daniel Allen for research assistance. Martha Madsen at Explore Kamchatka and Tom Quinn at Polar Field Services provided outstanding logistical support.
PY - 2011
Y1 - 2011
N2 - The use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neuropathology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neuroimaging data within the frameworks of a study of post-natal neuro-development in intra-uterine cocaine-exposure. We propose the use of non-invasive neuroimaging to study developmental brain structural and white matter pathway abnormalities via sMRI and DTI, as advanced MR imaging technology is readily available and automated image analysis methodology have recently been transferred from the human to animal imaging setting. For this purpose, we developed a synergistic, parallel approach to imaging and image analysis for the human and the rodent branch of our study. We propose an equivalent design in both the selection of the developmental assessment stage and the neuroimaging setup. This approach brings significant advantages to study neurobiological features of early brain development that are common to animals and humans but also preserve analysis capabilities only possible in animal research. This paper presents the main framework and individual methods for the proposed cross-species study design, as well as preliminary DTI cross-species comparative results in the intra-uterine cocaine-exposure study.
AB - The use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neuropathology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neuroimaging data within the frameworks of a study of post-natal neuro-development in intra-uterine cocaine-exposure. We propose the use of non-invasive neuroimaging to study developmental brain structural and white matter pathway abnormalities via sMRI and DTI, as advanced MR imaging technology is readily available and automated image analysis methodology have recently been transferred from the human to animal imaging setting. For this purpose, we developed a synergistic, parallel approach to imaging and image analysis for the human and the rodent branch of our study. We propose an equivalent design in both the selection of the developmental assessment stage and the neuroimaging setup. This approach brings significant advantages to study neurobiological features of early brain development that are common to animals and humans but also preserve analysis capabilities only possible in animal research. This paper presents the main framework and individual methods for the proposed cross-species study design, as well as preliminary DTI cross-species comparative results in the intra-uterine cocaine-exposure study.
KW - Brain segmentation
KW - Diffusion tensor imaging
KW - Drug abuse
KW - Magnetic resonance imaging
KW - Neonatal neuroimaging
KW - Small animal imaging
KW - White matter pathways
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UR - http://www.scopus.com/inward/citedby.url?scp=84866943212&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2011.00053
DO - 10.3389/fpsyt.2011.00053
M3 - Article
C2 - 22013425
AN - SCOPUS:84866943212
SN - 1664-0640
VL - 2
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
IS - OCT
M1 - Article 53
ER -