Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides

Warren S. Weiner, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.

Original languageEnglish (US)
Pages (from-to)681-686
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number6
DOIs
StatePublished - Mar 17 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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