Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides

Warren S. Weiner; Andrew D. Hamilton

doi:10.1016/S0960-894X(98)00099-7

Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides

Warren S. Weiner, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.

Original language	English (US)
Pages (from-to)	681-686
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(98)00099-7
State	Published - Mar 17 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00099-7

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title = "Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides",

abstract = "The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.",

author = "Weiner, {Warren S.} and Hamilton, {Andrew D.}",

note = "Funding Information: Acknowledgments: The financial support of The Petroleum Institute LTR grant No. 14502 is gratefully acknowledged. The cost of open access publishing is covered by the first author.",

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AU - Weiner, Warren S.

AU - Hamilton, Andrew D.

N1 - Funding Information: Acknowledgments: The financial support of The Petroleum Institute LTR grant No. 14502 is gratefully acknowledged. The cost of open access publishing is covered by the first author.

PY - 1998/3/17

Y1 - 1998/3/17

N2 - The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.

AB - The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.

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Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides

Abstract

ASJC Scopus subject areas

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