TY - JOUR
T1 - Synthesis and biological evaluation of (±)-hippolachnin and analogs
AU - Winter, Nils
AU - Rupcic, Zeljka
AU - Stadler, Marc
AU - Trauner, Dirk
N1 - Funding Information:
Acknowledgements We would like to thank Dr. Peter Mayer for X-ray structure analysis. Additionally, we would like to acknowledge the Deutsche Forschungsgemeinschaft (SFB 749 and CIPSM) for generous funding.
Publisher Copyright:
© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.
AB - Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.
UR - http://www.scopus.com/inward/record.url?scp=85064492300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064492300&partnerID=8YFLogxK
U2 - 10.1038/s41429-019-0176-x
DO - 10.1038/s41429-019-0176-x
M3 - Article
C2 - 30979942
AN - SCOPUS:85064492300
SN - 0021-8820
VL - 72
SP - 375
EP - 383
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 6
ER -