Synthesis and biological evaluation of (±)-hippolachnin and analogs

Nils Winter, Zeljka Rupcic, Marc Stadler, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalJournal of Antibiotics
Issue number6
StatePublished - Jun 1 2019

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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