Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

Chunhui Zhou; Jaeki Min; Zhigang Liu; Anne Young; Heather Deshazer; Tian Gao; Young Tae Chang; Neville R. Kallenbach

doi:10.1016/j.bmcl.2008.01.031

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

Chunhui Zhou, Jaeki Min, Zhigang Liu, Anne Young, Heather Deshazer, Tian Gao, Young Tae Chang, Neville R. Kallenbach

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.

Original language	English (US)
Pages (from-to)	1308-1311
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2008.01.031
State	Published - Feb 15 2008

Keywords

1,3,5-Triazine
Cationic antimicrobial peptide mimetic
Membranolytic

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.01.031

Cite this

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title = "Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents",

abstract = "Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.",

keywords = "1,3,5-Triazine, Cationic antimicrobial peptide mimetic, Membranolytic",

author = "Chunhui Zhou and Jaeki Min and Zhigang Liu and Anne Young and Heather Deshazer and Tian Gao and Chang, {Young Tae} and Kallenbach, {Neville R.}",

note = "Funding Information: This work was supported by a grant from ONR (N00014-03-1-0129). We acknowledge the NCRR/NIH for a Research Facilities Improvement Grant (C06 RR-16572) at NYU. The authors thank Brian Rasimick for helpful discussions.",

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AU - Zhou, Chunhui

AU - Min, Jaeki

AU - Liu, Zhigang

AU - Young, Anne

AU - Deshazer, Heather

AU - Gao, Tian

AU - Chang, Young Tae

AU - Kallenbach, Neville R.

N1 - Funding Information: This work was supported by a grant from ONR (N00014-03-1-0129). We acknowledge the NCRR/NIH for a Research Facilities Improvement Grant (C06 RR-16572) at NYU. The authors thank Brian Rasimick for helpful discussions.

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Y1 - 2008/2/15

N2 - Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.

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KW - Membranolytic

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Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

Abstract

Keywords

ASJC Scopus subject areas

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