Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

Chunhui Zhou, Jaeki Min, Zhigang Liu, Anne Young, Heather Deshazer, Tian Gao, Young Tae Chang, Neville R. Kallenbach

Research output: Contribution to journalArticle

Abstract

Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.

Original languageEnglish (US)
Pages (from-to)1308-1311
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number4
DOIs
StatePublished - Feb 15 2008

Keywords

  • 1,3,5-Triazine
  • Cationic antimicrobial peptide mimetic
  • Membranolytic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Zhou, C., Min, J., Liu, Z., Young, A., Deshazer, H., Gao, T., Chang, Y. T., & Kallenbach, N. R. (2008). Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Bioorganic and Medicinal Chemistry Letters, 18(4), 1308-1311. https://doi.org/10.1016/j.bmcl.2008.01.031