Abstract
A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Å apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry.
Original language | English (US) |
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Pages (from-to) | 4383-4386 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 38 |
Issue number | 25 |
DOIs | |
State | Published - Jun 23 1997 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry