Synthesis of a dinucleating ligand with addressed ion binding sites

Osvaldo Dos Santos; Ajay R. Lajmi; James W. Canary

doi:10.1016/S0040-4039(97)00937-4

Synthesis of a dinucleating ligand with addressed ion binding sites

Osvaldo Dos Santos, Ajay R. Lajmi, James W. Canary

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Å apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry.

Original language	English (US)
Pages (from-to)	4383-4386
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	25
DOIs	https://doi.org/10.1016/S0040-4039(97)00937-4
State	Published - Jun 23 1997

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)00937-4

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abstract = "A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 {\AA} apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry.",

author = "{Dos Santos}, Osvaldo and Lajmi, {Ajay R.} and Canary, {James W.}",

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AU - Lajmi, Ajay R.

AU - Canary, James W.

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N2 - A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Å apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry.

AB - A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Å apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry.

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Synthesis of a dinucleating ligand with addressed ion binding sites

Abstract

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