Synthesis of a dinucleating ligand with addressed ion binding sites

Osvaldo Dos Santos, Ajay R. Lajmi, James W. Canary

Research output: Contribution to journalArticlepeer-review


A ligand was synthesized that contains two binding sites, differentiated on the basis of size and donor atom. The binding profile for a series of amino acid guests suggest that the two binding sites are 6.5 Å apart. Kinetic studies of hydrolysis of a model phosphodiester substrate by heterodinuclear complexes of the ligand suggest that one metal ion delivers a hydroxide nucleophile and the other increases substrate binding although not in the ideal geometry.

Original languageEnglish (US)
Pages (from-to)4383-4386
Number of pages4
JournalTetrahedron Letters
Issue number25
StatePublished - Jun 23 1997

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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