Synthesis of a heterotelechelic helical poly(methacrylamide) and its incorporation into a supramolecular triblock copolymer

Ru Deng, Margarita Milton, Scott K. Pomarico, Marcus Weck

Research output: Contribution to journalArticlepeer-review

Abstract

We report the first heterotelechelic helical poly(methacrylamide) (PMAc) bearing orthogonal supramolecular binding sites on its chain-ends synthesized through a combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization and thiol-bromo "click" chemistry. The heterotelechelic PMAc was assembled with two monotelechelic polymers featuring different secondary structures, namely a coil-like poly(styrene) and a helical poly(isocyanide), resulting in the formation of a coil-helix-helix supramolecular triblock copolymer through orthogonal metal coordination and hydrogen bonding interactions. Triblock assembly was confirmed through 1H NMR spectroscopy, isothermal titration calorimetry (ITC) and viscometry. The individual polymer blocks retained their secondary structures in the final triblock copolymer, as evidenced by circular dichroism (CD) spectroscopy. Our synthetic strategy expands the toolbox of triblock copolymers featuring structural motifs similar to the ones found in proteins and provides the potential for the development of other complex multifunctional polymeric ensembles.

Original languageEnglish (US)
Pages (from-to)5087-5093
Number of pages7
JournalPolymer Chemistry
Volume10
Issue number37
DOIs
StatePublished - Oct 7 2019

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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