Synthesis of artificial receptors as potential candidates for recognition and binding of pterin analogs

Maria V. Papadopoulou, Shyamaprosad Goswami, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Open chain podands 2a‐c and macrocycles 2d‐e have been synthesized as potential candidates for 4‐aminopterin recognition and binding, featuring Hbonding characteristics and “stacking interaction” 2e. Preliminary binding studies between 6, 7, and 8 (simpler analogs of the above 2a‐e) as “bosts” and appropriate “guests”, showed that carbamates 2a and 2e are the most promising receptors for 4‐aminopterin binding.

Original languageEnglish (US)
Pages (from-to)675-681
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume32
Issue number2
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Organic Chemistry

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