Synthesis of Bridged Diketopiperazines by Using the Persistent Radical Effect and a Formal Synthesis of Bicyclomycin

Tynchtyk Amatov; Radek Pohl; Ivana Císařová; Ullrich Jahn

doi:10.1002/anie.201504883

Synthesis of Bridged Diketopiperazines by Using the Persistent Radical Effect and a Formal Synthesis of Bicyclomycin

Tynchtyk Amatov, Radek Pohl, Ivana Císařová, Ullrich Jahn

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A conceptually new and unified approach to diverse bridged diketopiperazines (DKPs) with widely variable ring sizes was developed by taking advantage of the persistent radical effect. This method enables synthesis of the core structures of bridged DKP alkaloids and was applied to a formal synthesis of the antibiotic bicyclomycin.

Original language	English (US)
Pages (from-to)	12153-12157
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	41
DOIs	https://doi.org/10.1002/anie.201504883
State	Published - Oct 1 2015

Keywords

alkaloids
bicyclomycin
bridged diketopiperazines
cyclization
radicals

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201504883

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AU - Jahn, Ullrich

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KW - cyclization

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Synthesis of Bridged Diketopiperazines by Using the Persistent Radical Effect and a Formal Synthesis of Bicyclomycin

Abstract

Keywords

ASJC Scopus subject areas

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