Synthesis of Bridged Diketopiperazines by Using the Persistent Radical Effect and a Formal Synthesis of Bicyclomycin

Tynchtyk Amatov, Radek Pohl, Ivana Císařová, Ullrich Jahn

Research output: Contribution to journalArticlepeer-review

Abstract

A conceptually new and unified approach to diverse bridged diketopiperazines (DKPs) with widely variable ring sizes was developed by taking advantage of the persistent radical effect. This method enables synthesis of the core structures of bridged DKP alkaloids and was applied to a formal synthesis of the antibiotic bicyclomycin.

Original languageEnglish (US)
Pages (from-to)12153-12157
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number41
DOIs
StatePublished - Oct 1 2015

Keywords

  • alkaloids
  • bicyclomycin
  • bridged diketopiperazines
  • cyclization
  • radicals

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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