α,β-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd(DMSO) 2(TFA) 2 as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O 2 as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product precursors.
ASJC Scopus subject areas
- Colloid and Surface Chemistry