Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones

Tianning Diao, Shannon S. Stahl

Research output: Contribution to journalArticlepeer-review

Abstract

α,β-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd(DMSO) 2(TFA) 2 as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O 2 as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product precursors.

Original languageEnglish (US)
Pages (from-to)14566-14569
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number37
DOIs
StatePublished - Sep 21 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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