Synthesis of first- and second-generation poly(amide)-dendronized polymers via ring-opening metathesis polymerization

Hwayoon Jung, Tom P. Carberry, Marcus Weck

Research output: Contribution to journalArticlepeer-review

Abstract

First- and second-generation Newkome-type dendronized norbornene macromonomers were synthesized and polymerized by ring-opening metathesis polymerization (ROMP). In the case of the second-generation macromonomer, the rate of polymerization was highly dependent on the initial concentration of the macromonomer; quasi-quantitative polymerization was only achieved when the concentration was higher than 50 mM. Adding a linker between the polymerizable group and the dendron increased the rate of polymerization and it was possible to reach quantitative conversions at lower concentration. Doubling the length of the linker further improved the polymerization to a rate comparable with the polymerization of the first-generation dendronized macromonomer. The dendronized polymers presented herein consist of a poly(amide)-based dendron attached to the poly(norbornene) backbone. Because of the properties of these components such as biocompatibility, we foresee these polymers having possible applications in therapeutics.

Original languageEnglish (US)
Pages (from-to)9075-9083
Number of pages9
JournalMacromolecules
Volume44
Issue number23
DOIs
StatePublished - Dec 13 2011

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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