Synthesis of high throughput ibuprofen nanoparticles via supercritical CO2 processing

Sudhir Kumar Sharma, Ramesh Jagannathan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High throughput ibuprofen nanoparticles with a yield up to 80 % (w/w) are synthesized via supersonic jet expansion of the supercritical CO2 processing. The effect of four different surfactants on the size of ibuprofen nanoparticles were investigated. Drop casting of these aqueous solutions on a quartz substrate and resulted in stable, viscous liquid films observed by optical, atomic force microscopy (AFM) and scanning electron microscopy (SEM). X-ray diffraction (XRD) and confocal Raman confirmed that these nanoparticles have retained their structural and chemical identity after rapid expansion of a supercritical solution (RESS) processing.

Original languageEnglish (US)
Title of host publication19th IEEE International Conference on Nanotechnology, NANO 2019
PublisherIEEE Computer Society
Pages203-206
Number of pages4
ISBN (Electronic)9781728128917
DOIs
StatePublished - Jul 2019
Event19th IEEE International Conference on Nanotechnology, NANO 2019 - Macau, China
Duration: Jul 22 2019Jul 26 2019

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
Volume2019-July
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Conference

Conference19th IEEE International Conference on Nanotechnology, NANO 2019
CountryChina
CityMacau
Period7/22/197/26/19

Keywords

  • Ibuprofen nanoparticles
  • RESS
  • Supercritical fluids

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

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  • Cite this

    Sharma, S. K., & Jagannathan, R. (2019). Synthesis of high throughput ibuprofen nanoparticles via supercritical CO2 processing. In 19th IEEE International Conference on Nanotechnology, NANO 2019 (pp. 203-206). [8993945] (Proceedings of the IEEE Conference on Nanotechnology; Vol. 2019-July). IEEE Computer Society. https://doi.org/10.1109/NANO46743.2019.8993945