Synthesis of silyl monoperoxyketals by regioselective cobalt-catalyzed peroxidation of silyl enol ethers: Application to the synthesis of 1,2-dioxolanes

Brisa Hurlocker, Matthew R. Miner, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

The cobalt-catalyzed peroxidation of silyl enol ethers with molecular oxygen and triethylsilane provided silyl monoperoxyketals in 54%-96% yield. These compounds serve as precursors to peroxycarbenium ions, which undergo annulations to provide 1,2-dioxolanes.

Original languageEnglish (US)
Pages (from-to)4280-4283
Number of pages4
JournalOrganic Letters
Volume16
Issue number16
DOIs
StatePublished - Aug 15 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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