Synthesis of tertiary α-hydroxy acids by silylene transfer to α-keto esters

Brett E. Howard, K. A. Woerpel

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) α-Keto esters can be converted into α-hydroxy acids in a single flask involving metal-catalyzed silylene transfer, 6π-electrocyclization, Ireland-Claisen rearrangement, and hydrolysis. This reaction sequence is stereoselective and tolerates alkyl- and aryl-substituted α-keto ester substrates as well as an α-imino ester.

Original languageEnglish (US)
Pages (from-to)4651-4653
Number of pages3
JournalOrganic Letters
Volume9
Issue number22
DOIs
StatePublished - Oct 25 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of tertiary α-hydroxy acids by silylene transfer to α-keto esters'. Together they form a unique fingerprint.

  • Cite this