Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions

Oleg V. Kulikov; Andrew D. Hamilton

doi:10.1039/c2ra01153k

Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions

Oleg V. Kulikov, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of the family of new non-natural trimeric oligobenzamides (potential inhibitors of protein-protein interactions) bearing the following groups (R = isobutyl, isopropyl, CH ₂CONH ₂, (CH ₂) ₄NH ₂, benzyl) that mimic different amino acid residues (leucine, valine, asparagine, lysine, phenylalanine) was accomplished through an iterative (n + 1) elongation approach that includes reduction of the NO ₂-group (Pd/C, H ₂) and subsequent amide coupling in the presence of Mukaiyama's reagent.

Original language	English (US)
Pages (from-to)	2454-2461
Number of pages	8
Journal	RSC Advances
Volume	2
Issue number	6
DOIs	https://doi.org/10.1039/c2ra01153k
State	Published - Mar 14 2012

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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abstract = "The synthesis of the family of new non-natural trimeric oligobenzamides (potential inhibitors of protein-protein interactions) bearing the following groups (R = isobutyl, isopropyl, CH 2CONH 2, (CH 2) 4NH 2, benzyl) that mimic different amino acid residues (leucine, valine, asparagine, lysine, phenylalanine) was accomplished through an iterative (n + 1) elongation approach that includes reduction of the NO 2-group (Pd/C, H 2) and subsequent amide coupling in the presence of Mukaiyama's reagent.",

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Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions

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