Synthesis of tris((3-isoquinolyl)methyl)amine and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine

Jinqi Xu; Chang Lin Chuang; James W. Canary

doi:10.1016/S0020-1693(96)05404-7

Synthesis of tris((3-isoquinolyl)methyl)amine and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine

Jinqi Xu, Chang Lin Chuang, James W. Canary

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The tripodal ligands tris((3-isoquinolyl)methyl)amine (TIQA) and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine were synthesized from isoquinoline-3-carboxylic acid in four steps and 28 and 31% overall yield, respectively. These ligands are structurally related to the important ligand tris((2-pyridyl)methyl)amine (TPA). Electrospray ionization mass spectrometry experiments indicate that TIQA forms complexes with CuCl₂, ZnCl₂ and CdI₂ similar to those observed with TPA.

Original language	English (US)
Pages (from-to)	125-128
Number of pages	4
Journal	Inorganica Chimica Acta
Volume	256
Issue number	1
DOIs	https://doi.org/10.1016/S0020-1693(96)05404-7
State	Published - Mar 15 1997

Keywords

Electrospray ionization mass spectrometry
Isoquinoline ligand
Tripodal ligand

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/S0020-1693(96)05404-7

Cite this

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title = "Synthesis of tris((3-isoquinolyl)methyl)amine and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine",

abstract = "The tripodal ligands tris((3-isoquinolyl)methyl)amine (TIQA) and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine were synthesized from isoquinoline-3-carboxylic acid in four steps and 28 and 31% overall yield, respectively. These ligands are structurally related to the important ligand tris((2-pyridyl)methyl)amine (TPA). Electrospray ionization mass spectrometry experiments indicate that TIQA forms complexes with CuCl2, ZnCl2 and CdI2 similar to those observed with TPA.",

keywords = "Electrospray ionization mass spectrometry, Isoquinoline ligand, Tripodal ligand",

author = "Jinqi Xu and Chuang, {Chang Lin} and Canary, {James W.}",

note = "Funding Information: We thank the National Institutes of Health (GM 49170) for support of this research. Some mass spectra were obtained at the Michigan State University Mass Spectrometry Facility (supported in part by grant DRR-00480, from the Biotechnology Research Technology Program, NCRS, NIH). ",

year = "1997",

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doi = "10.1016/S0020-1693(96)05404-7",

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pages = "125--128",

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TY - JOUR

T1 - Synthesis of tris((3-isoquinolyl)methyl)amine and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine

AU - Xu, Jinqi

AU - Chuang, Chang Lin

AU - Canary, James W.

N1 - Funding Information: We thank the National Institutes of Health (GM 49170) for support of this research. Some mass spectra were obtained at the Michigan State University Mass Spectrometry Facility (supported in part by grant DRR-00480, from the Biotechnology Research Technology Program, NCRS, NIH).

PY - 1997/3/15

Y1 - 1997/3/15

N2 - The tripodal ligands tris((3-isoquinolyl)methyl)amine (TIQA) and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine were synthesized from isoquinoline-3-carboxylic acid in four steps and 28 and 31% overall yield, respectively. These ligands are structurally related to the important ligand tris((2-pyridyl)methyl)amine (TPA). Electrospray ionization mass spectrometry experiments indicate that TIQA forms complexes with CuCl2, ZnCl2 and CdI2 similar to those observed with TPA.

AB - The tripodal ligands tris((3-isoquinolyl)methyl)amine (TIQA) and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine were synthesized from isoquinoline-3-carboxylic acid in four steps and 28 and 31% overall yield, respectively. These ligands are structurally related to the important ligand tris((2-pyridyl)methyl)amine (TPA). Electrospray ionization mass spectrometry experiments indicate that TIQA forms complexes with CuCl2, ZnCl2 and CdI2 similar to those observed with TPA.

KW - Electrospray ionization mass spectrometry

KW - Isoquinoline ligand

KW - Tripodal ligand

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JO - Inorganica Chimica Acta

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IS - 1

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Synthesis of tris((3-isoquinolyl)methyl)amine and bis((2-pyridyl)methyl)-(3-isoquinolyl)methylamine

Abstract

Keywords

ASJC Scopus subject areas

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