Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation

Ishu Saraogi, James A. Hebda, Jorge Becerril, Lara A. Estroff, Andrew D. Miranker, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP.

Original languageEnglish (US)
Pages (from-to)736-739
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number4
DOIs
StatePublished - Jan 18 2010

Keywords

  • Amyloid β-peptides
  • Diabetes
  • Helical structures
  • Proteomimetics
  • α-helix mimetics

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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