Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation

Ishu Saraogi; James A. Hebda; Jorge Becerril; Lara A. Estroff; Andrew D. Miranker; Andrew D. Hamilton

doi:10.1002/anie.200901694

Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation

Ishu Saraogi, James A. Hebda, Jorge Becerril, Lara A. Estroff, Andrew D. Miranker, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP.

Original language	English (US)
Pages (from-to)	736-739
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	4
DOIs	https://doi.org/10.1002/anie.200901694
State	Published - Jan 18 2010

Keywords

Amyloid β-peptides
Diabetes
Helical structures
Proteomimetics
α-helix mimetics

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200901694

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abstract = "Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP.",

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AU - Miranker, Andrew D.

AU - Hamilton, Andrew D.

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AB - Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP.

KW - Amyloid β-peptides

KW - Diabetes

KW - Helical structures

KW - Proteomimetics

KW - α-helix mimetics

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Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation

Abstract

Keywords

ASJC Scopus subject areas

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