Synthetic approaches towards alkaloids bearing α-tertiary amines

Anastasia Hager, Nina Vrielink, Dominik Hager, Julien Lefranc, Dirk Trauner

Research output: Contribution to journalReview articlepeer-review


Covering: up to August 2015 Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs. Amongst these, the α-tertiary amine (ATA), i.e. a tetrasubstituted carbon atom surrounded by three carbons and one nitrogen, is particularly interesting. A limited number of methods have been described to access this functional group and fewer still are commonly used in synthesis. Herein, we review some approaches to asymmetrically access ATAs and provide an overview of alkaloid total syntheses where those have been employed.

Original languageEnglish (US)
Pages (from-to)491-522
Number of pages32
JournalNatural Product Reports
Issue number3
StatePublished - Mar 2016

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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