Synthetic Strategies Toward DNA-Coated Colloids that Crystallize

Yufeng Wang, Yu Wang, Xiaolong Zheng, Étienne Ducrot, Myung Goo Lee, Gi Ra Yi, Marcus Weck, David J. Pine

Research output: Contribution to journalArticlepeer-review

Abstract

We report on synthetic strategies to fabricate DNA-coated micrometer-sized colloids that, upon thermal annealing, self-assemble into various crystal structures. Colloids of a wide range of chemical compositions, including poly(styrene), poly(methyl methacrylate), titania, silica, and a silica-methacrylate hybrid material, are fabricated with smooth particle surfaces and a dense layer of surface functional anchors. Single-stranded oligonucleotides with a short sticky end are covalently grafted onto particle surfaces employing a strain-promoted alkyne-azide cycloaddition reaction resulting in DNA coatings with areal densities an order of magnitude higher than previously reported. Our approach allows the DNA-coated colloids not only to aggregate upon cooling but also to anneal and rearrange while still bound together, leading to the formation of colloidal crystal compounds when particles of different sizes or different materials are combined.

Original languageEnglish (US)
Pages (from-to)10760-10766
Number of pages7
JournalJournal of the American Chemical Society
Volume137
Issue number33
DOIs
StatePublished - Jul 20 2015

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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