TY - JOUR
T1 - Systematic latency variation of the auditory evoked M100
T2 - From average to single-trial data
AU - Salajegheh, A.
AU - Link, A.
AU - Elster, C.
AU - Burghoff, M.
AU - Sander, T.
AU - Trahms, L.
AU - Poeppel, D.
N1 - Funding Information:
During the preparation of this manuscript, DP was a Fellow at the Wissenschaftskolleg zu Berlin. DP and AS were supported by NIH RO1 DC05660. TS was supported by the Berlin Neuroimaging Center (BNIC, supported by BMFB). Special thanks to the reviewers for thoughtful critical comments and suggestions as well as Profs. Jim Hunt, Dominique Pestre, and Beate Rössler for providing their brains.
PY - 2004/9
Y1 - 2004/9
N2 - Standard analyses of neurophysiologically evoked response data rely on signal averaging across many epochs associated with specific events. The amplitudes and latencies of these averaged events are subsequently interpreted in the context of the given perceptual, motor, or cognitive tasks. Can such critical timing properties of event-related responses be recovered from single-trial data? Here, we make use of the M100 latency paradigm used in previous magnetoencephalography (MEG) research to evaluate a novel single-trial analysis approach. Specifically, the latency of the auditory evoked M100 varies systematically with stimulus frequency over a well-defined time range (lower frequencies, e.g., 125 Hz, yield up to 25 ms longer latencies than higher frequencies, e.g., 1000 Hz). Here, we show that the complex filtering approach to single-trial analysis recovers this key characteristic of the M100 response, as well as some other important response properties relating to lateralization. The results illustrate (i) the utility of the complex filtering method and (ii) the potential of the M100 latency to be used for stimulus encoding, since the relevant variation can be observed in single trials.
AB - Standard analyses of neurophysiologically evoked response data rely on signal averaging across many epochs associated with specific events. The amplitudes and latencies of these averaged events are subsequently interpreted in the context of the given perceptual, motor, or cognitive tasks. Can such critical timing properties of event-related responses be recovered from single-trial data? Here, we make use of the M100 latency paradigm used in previous magnetoencephalography (MEG) research to evaluate a novel single-trial analysis approach. Specifically, the latency of the auditory evoked M100 varies systematically with stimulus frequency over a well-defined time range (lower frequencies, e.g., 125 Hz, yield up to 25 ms longer latencies than higher frequencies, e.g., 1000 Hz). Here, we show that the complex filtering approach to single-trial analysis recovers this key characteristic of the M100 response, as well as some other important response properties relating to lateralization. The results illustrate (i) the utility of the complex filtering method and (ii) the potential of the M100 latency to be used for stimulus encoding, since the relevant variation can be observed in single trials.
KW - Auditory N1
KW - MEG
KW - Magnetoencephalography
KW - N1m
KW - Single-trial EP analysis
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U2 - 10.1016/j.neuroimage.2004.05.022
DO - 10.1016/j.neuroimage.2004.05.022
M3 - Article
C2 - 15325376
AN - SCOPUS:4344665625
SN - 1053-8119
VL - 23
SP - 288
EP - 295
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -