Machine-to-Machine (M2M) communication is one of the newest research fields today and is expected to play a vital role in business areas such as e-healthcare, logistics etc. Mobile communication standards, such as Long Term Evolution Advanced (LTE-A) are designed to provide high data rate and broadband services to human-based communication. However, the nature of M2M traffic is different as terminals usually have to transmit small amounts of data infrequently. In this paper, we evaluate an LTE-A Relay Node (RN) based solution to integrate M2M devices into mobile cellular networks. We develop an M2M scenario consisting of both e-healthcare and logistic devices along with normal LTE-A users in our simulation model using OPNET modeler. The simulation results indicate the better performance of LTE-A network if RN is used for the multiplexing and aggregation of M2M data traffic.