Tailoring of block copolymers based on the stoichiometric control of the end-functionality of telechelic oligomers and the utilization of large-scale fractionation by phase fluctuation chromatography: a synthetic strategy for the preparation of end-functionalized poly(L-lactide)-block- poly(oxyethylene)

Tomoko Fujiwara, Yoshiharu Kimura, Iwao Teraoka

Research output: Contribution to journalArticle

Abstract

An AB diblock copolymer of poly(L-lactide) (PLLA) and poly(oxyethylene) (PEG) with a cinnamate terminal in the PEG block was prepared by the copolymerization of L-lactide and partially end-modified PEG followed by fractionation. The first step was the terminal modification of PEG with cinnamoyl chloride (CC), in which the degree of cinnamoylation of the hydroxyl terminals of PEG was roughly controlled by the feed ratio of both reactants. The resultant PEG cinnamate was subjected to copolymerization with L-lactide to produce a mixture of unreacted PEG dicinnamate (C-PEG-C), the diblock copolymer (PLLA-PEG-C), and the triblock copolymer (PLLA-PEG-PLLA) corresponding to the three components of the PEG cinnamate. This mixture was separated by phase fluctuation chromatography (PFC) to obtain PLLA-PEG-C in sufficient purity. This process, involving the stoichiometric control of the terminal reaction of telechelic oligomers and the utilization of PFC for fractionation, can be an efficient method for synthesizing end-functionalized diblock copolymers from readily available telechelic oligomers.

Original languageEnglish (US)
Pages (from-to)2405-2414
Number of pages10
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume38
Issue number13
DOIs
StatePublished - Jul 1 2000

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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