Taking whispering gallery mode biosensing to the single protein limit

Steve Arnold, V. R. Dantham, N. Rivilis, S. Holler

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Finding a method for label-free sensing of individual protein is considered the "Holy Grail" in the bio-sensing field. An ideal technology that could do this would be able to follow the sensing of biological antigen-antibody interactions in their native form and in real-time without interfering tags. The challenge is great, however the rewards are likely greater. To date the most sensitive photonic label-free transducer is a resonant biosensor in the form of a Ring Resonator or Whispering Gallery Mode (WGM) resonator for which there have been a number of recent reviews [1, 2].

Original languageEnglish (US)
Title of host publicationNano-Optics for Enhancing Light-Matter Interactions on a Molecular Scale
Subtitle of host publicationPlamonics, Photonic Materials and Sub-Wavelength Resolution
EditorsBaldassare Di Bartolo, Luciano Silvestri, John Collins
Pages271-285
Number of pages15
DOIs
StatePublished - 2013

Publication series

NameNATO Science for Peace and Security Series B: Physics and Biophysics
ISSN (Print)1874-6500

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Physics and Astronomy(all)
  • Electrical and Electronic Engineering

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  • Cite this

    Arnold, S., Dantham, V. R., Rivilis, N., & Holler, S. (2013). Taking whispering gallery mode biosensing to the single protein limit. In B. Di Bartolo, L. Silvestri, & J. Collins (Eds.), Nano-Optics for Enhancing Light-Matter Interactions on a Molecular Scale: Plamonics, Photonic Materials and Sub-Wavelength Resolution (pp. 271-285). (NATO Science for Peace and Security Series B: Physics and Biophysics). https://doi.org/10.1007/978-94-007-5313-6-12