Taking whispering gallery-mode single virus detection and sizing to the limit

V. R. Dantham; S. Holler; V. Kolchenko; Z. Wan; S. Arnold

doi:10.1063/1.4739473

Taking whispering gallery-mode single virus detection and sizing to the limit

V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, S. Arnold

Research output: Contribution to journal › Article › peer-review

Abstract

We report the label-free detection and sizing by a microcavity of the smallest individual RNA virus, MS2, with a mass only ∼1 of InfluenzaA (6 vs. 512 ag). Although detection of such a small bio-nano-particle has been beyond the reach of a bare spherical microcavity, it was accomplished with ease (S/N 8, Q 4 × 10 ⁵) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer, providing an enhancement of ∼70×, in agreement with theory. Unique wavelength shift statistics are recorded consistent with an ultra-uniform genetically programmed substance that is drawn to the plasmonic hot spots by light-forces.

Original language	English (US)
Article number	043704
Journal	Applied Physics Letters
Volume	101
Issue number	4
DOIs	https://doi.org/10.1063/1.4739473
State	Published - Jul 23 2012

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.4739473

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title = "Taking whispering gallery-mode single virus detection and sizing to the limit",

abstract = "We report the label-free detection and sizing by a microcavity of the smallest individual RNA virus, MS2, with a mass only ∼1 of InfluenzaA (6 vs. 512 ag). Although detection of such a small bio-nano-particle has been beyond the reach of a bare spherical microcavity, it was accomplished with ease (S/N 8, Q 4 × 10 5) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer, providing an enhancement of ∼70×, in agreement with theory. Unique wavelength shift statistics are recorded consistent with an ultra-uniform genetically programmed substance that is drawn to the plasmonic hot spots by light-forces.",

author = "Dantham, {V. R.} and S. Holler and V. Kolchenko and Z. Wan and S. Arnold",

note = "Funding Information: The authors thank the NSF for supporting this work (Grant No. CBET 0933531). We also wish to thank N. L. Goddard of Hunter College for making her student Z. Wan available for preparing the MS2 virus.",

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AU - Dantham, V. R.

AU - Holler, S.

AU - Kolchenko, V.

AU - Wan, Z.

AU - Arnold, S.

N1 - Funding Information: The authors thank the NSF for supporting this work (Grant No. CBET 0933531). We also wish to thank N. L. Goddard of Hunter College for making her student Z. Wan available for preparing the MS2 virus.

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AB - We report the label-free detection and sizing by a microcavity of the smallest individual RNA virus, MS2, with a mass only ∼1 of InfluenzaA (6 vs. 512 ag). Although detection of such a small bio-nano-particle has been beyond the reach of a bare spherical microcavity, it was accomplished with ease (S/N 8, Q 4 × 10 5) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer, providing an enhancement of ∼70×, in agreement with theory. Unique wavelength shift statistics are recorded consistent with an ultra-uniform genetically programmed substance that is drawn to the plasmonic hot spots by light-forces.

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Taking whispering gallery-mode single virus detection and sizing to the limit

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