Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly

Steven Isaacman, Michael Buckley, Xiaojian Wang, Edwin Y. Wang, Leonard Liebes, James W. Canary

Research output: Contribution to journalArticle

Abstract

Nanometer-scale architectures assembled on cell surface receptors from smaller macromolecular constituents generated a large amplification of fluorescence. A targeted dendrimer was synthesized from a cystamine-core G4 PAMAM dendrimer, and contained an anti-BrE3 monoclonal antibody as the targeting group, several fluorophores and an average of 12 aldehyde moieties as complementary bio-orthogonal reactive sites for the covalent assembly. A cargo dendrimer, derived from a PAMAM G4 dendrimer, contained several fluorophores as the cargo for delivery and five hydrazine moieties as complimentary bio-orthogonal reactive sites. The system is designed to be flexible and allow for facile incorporation of a variety of targeting ligands.

Original languageEnglish (US)
Pages (from-to)1290-1293
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number5
DOIs
StatePublished - Mar 1 2014

Keywords

  • Cell surface self-assembly
  • Dendrimer
  • Targeted amplification

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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