Targeting endosomal receptors, a new direction for polymers in nanomedicine

Paulina D. Ramirez-Garcia, Nicholas A. Veldhuis, Nigel W. Bunnett, Thomas P. Davis

Research output: Contribution to journalReview articlepeer-review


In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments. We discuss the specific example of antagonizing endosomal receptors involved in pain to develop long-lasting analgesics but also outline the broader application potential of this delivery approach. We discuss the materials used to target endosomal receptors and indicate the design requirements for future successful applications.

Original languageEnglish (US)
Pages (from-to)5390-5399
Number of pages10
JournalJournal of Materials Chemistry B
Issue number24
StatePublished - May 22 2023

ASJC Scopus subject areas

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science


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