Targeting of Transient Receptor Potential Channels in Digestive Disease

Daniel P. Poole; Tina Marie Lieu; Nicholas A. Veldhuis; Pradeep Rajasekhar; Nigel W. Bunnett

doi:10.1016/B978-0-12-420024-1.00021-7

Targeting of Transient Receptor Potential Channels in Digestive Disease

Daniel P. Poole, Tina Marie Lieu, Nicholas A. Veldhuis, Pradeep Rajasekhar, Nigel W. Bunnett

Molecular Pathobiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Transient Receptor Potential (TRP) channels are expressed throughout the gastrointestinal tract and have functional roles as detectors of taste and visceral sensation, as well as mediators of motility and secretion. Altered TRP expression or dysregulation of TRP channel function is associated with the etiology of gastrointestinal disease, including visceral pain, inflammatory bowel disease, pancreatitis and gastroesophageal reflux disease. This chapter summarizes the expression and functional roles of TRP channels in the gastrointestinal tract. The role of TRP channels in the development and maintenance of digestive diseases and the therapeutic potential of TRP channel modulators is also provided.

Original language	English (US)
Title of host publication	TRP Channels as Therapeutic Targets
Subtitle of host publication	From Basic Science to Clinical Use
Publisher	Elsevier Inc.
Pages	385-403
Number of pages	19
ISBN (Electronic)	9780124200791
ISBN (Print)	9780124200241
DOIs	https://doi.org/10.1016/B978-0-12-420024-1.00021-7
State	Published - Apr 8 2015

Keywords

Inflammatory bowel disease
Irritable bowel syndrome
Motility
Neurogenic inflammation
TRP channels
Visceral pain

ASJC Scopus subject areas

General Medicine
General Social Sciences

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10.1016/B978-0-12-420024-1.00021-7

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title = "Targeting of Transient Receptor Potential Channels in Digestive Disease",

abstract = "Transient Receptor Potential (TRP) channels are expressed throughout the gastrointestinal tract and have functional roles as detectors of taste and visceral sensation, as well as mediators of motility and secretion. Altered TRP expression or dysregulation of TRP channel function is associated with the etiology of gastrointestinal disease, including visceral pain, inflammatory bowel disease, pancreatitis and gastroesophageal reflux disease. This chapter summarizes the expression and functional roles of TRP channels in the gastrointestinal tract. The role of TRP channels in the development and maintenance of digestive diseases and the therapeutic potential of TRP channel modulators is also provided.",

keywords = "Inflammatory bowel disease, Irritable bowel syndrome, Motility, Neurogenic inflammation, TRP channels, Visceral pain",

author = "Poole, {Daniel P.} and Lieu, {Tina Marie} and Veldhuis, {Nicholas A.} and Pradeep Rajasekhar and Bunnett, {Nigel W.}",

note = "Funding Information: We thank Professor John Furness and Dr. Hyun Jung Cho (The Department of Anatomy & Neuroscience, The University of Melbourne, Australia) for assistance with figure preparation. Research in the authors{\textquoteright} laboratories has been supported by the National Health & Medical Research Council (Australia), The Australian Research Council, and Monash University. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved.",

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doi = "10.1016/B978-0-12-420024-1.00021-7",

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AU - Poole, Daniel P.

AU - Lieu, Tina Marie

AU - Veldhuis, Nicholas A.

AU - Rajasekhar, Pradeep

AU - Bunnett, Nigel W.

N1 - Funding Information: We thank Professor John Furness and Dr. Hyun Jung Cho (The Department of Anatomy & Neuroscience, The University of Melbourne, Australia) for assistance with figure preparation. Research in the authors’ laboratories has been supported by the National Health & Medical Research Council (Australia), The Australian Research Council, and Monash University. Publisher Copyright: © 2015 Elsevier Inc. All rights reserved.

PY - 2015/4/8

Y1 - 2015/4/8

N2 - Transient Receptor Potential (TRP) channels are expressed throughout the gastrointestinal tract and have functional roles as detectors of taste and visceral sensation, as well as mediators of motility and secretion. Altered TRP expression or dysregulation of TRP channel function is associated with the etiology of gastrointestinal disease, including visceral pain, inflammatory bowel disease, pancreatitis and gastroesophageal reflux disease. This chapter summarizes the expression and functional roles of TRP channels in the gastrointestinal tract. The role of TRP channels in the development and maintenance of digestive diseases and the therapeutic potential of TRP channel modulators is also provided.

AB - Transient Receptor Potential (TRP) channels are expressed throughout the gastrointestinal tract and have functional roles as detectors of taste and visceral sensation, as well as mediators of motility and secretion. Altered TRP expression or dysregulation of TRP channel function is associated with the etiology of gastrointestinal disease, including visceral pain, inflammatory bowel disease, pancreatitis and gastroesophageal reflux disease. This chapter summarizes the expression and functional roles of TRP channels in the gastrointestinal tract. The role of TRP channels in the development and maintenance of digestive diseases and the therapeutic potential of TRP channel modulators is also provided.

KW - Inflammatory bowel disease

KW - Irritable bowel syndrome

KW - Motility

KW - Neurogenic inflammation

KW - TRP channels

KW - Visceral pain

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SN - 9780124200241

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EP - 403

BT - TRP Channels as Therapeutic Targets

PB - Elsevier Inc.

ER -

Targeting of Transient Receptor Potential Channels in Digestive Disease

Abstract

Keywords

ASJC Scopus subject areas

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