Targeting peptides transiently block a mitochondrial channel

Timothy A. Lohret, Kathleen W. Kinnally

    Research output: Contribution to journalArticlepeer-review


    The effects of synthetic targeting peptides on the activity of the multiple conductance channel (MCC) of mouse and yeast mitochondria were investigated using patch-clamp techniques. Amino-terminal targeting peptides of two inner membrane proteins reversibly decreased the open probability and mean open time of MCC. One of these targeting peptides had no effect on two other voltage-dependent mitochondrial channels. Furthermore, the effects induced by the two targeting peptides on MCC were not elicited by two peptides of an outer membrane protein. The specific interactions of targeting peptides with MCC suggest that this channel may be involved in protein import across the inner mitochondrial membrane.

    Original languageEnglish (US)
    Pages (from-to)15950-15953
    Number of pages4
    JournalJournal of Biological Chemistry
    Issue number27
    StatePublished - Jul 7 1995

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology


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