Telencephalic cells take a tangent: Non-radial migration in the mammalian forebrain

Joshua G. Corbin, Susana Nery, Gord Fishell

Research output: Contribution to journalReview articlepeer-review


During development of the mammalian telencephalon, cells migrate via diverse pathways to reach their final destinations. In the developing neocortex, projection neurons are generated from cells that migrate radially from the underlying ventricular zone. In contrast, subsets of cells that populate the ventral piriform cortex and olfactory bulb reach these sites by migrating long distances. Additionally, it has been recently established that cells migrate tangentially from the ventral ganglionic eminences to the developing cortex. These tangentially migrating cells are a significant source of cortical interneurons and possibly other cell types such as oligodendrocytes. Here we summarize the known routes of migration in the developing telencephalon, with a particular focus on tangential migration. We also review recent genetic and transplantation studies that have given greater insight into the understanding of these processes and the molecular cues that may guide these migrating cells.

Original languageEnglish (US)
Pages (from-to)1177-1182
Number of pages6
JournalNature Neuroscience
Issue number11s
StatePublished - Nov 2001

ASJC Scopus subject areas

  • General Neuroscience


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