TY - JOUR
T1 - Temporal requirement of C/EBP in the amygdala following reactivation but not acquisition of inhibitory avoidance
AU - Milekic, Maria H.
AU - Pollonini, Gabriella
AU - Alberini, Cristina M.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/7
Y1 - 2007/7
N2 - Following learning, a memory is fragile and undergoes a protein synthesis-dependent consolidation process in order to become stable. Established memories can again become transiently sensitive to disruption if reactivated and require another protein synthesis-dependent process, known as reconsolidation, in order to persist. Here, we show that, in the basolateral amygdala (BLA), protein synthesis is necessary for both consolidation and reconsolidation of inhibitory avoidance (IA) memory, while the expression of the transcription factor CCAAT enhancer binding protein β (C/EBPβ) is essential only for the reconsolidation process. Moreover, the critical roles of both protein synthesis and C/EBPβ following IA reactivation are temporally restricted, as they are necessary only for recent but not old IA memories. These results, together with previous findings showing that in the hippocampus both protein synthesis and C/EBPβ expression are required for consolidation but not reconsolidation of IA indicate that the stabilization process that takes place either after training or memory retrieval engages distinct neural circuits. Within these circuits, the C/EBPβ-dependent molecular pathway appears to be differentially recruited.
AB - Following learning, a memory is fragile and undergoes a protein synthesis-dependent consolidation process in order to become stable. Established memories can again become transiently sensitive to disruption if reactivated and require another protein synthesis-dependent process, known as reconsolidation, in order to persist. Here, we show that, in the basolateral amygdala (BLA), protein synthesis is necessary for both consolidation and reconsolidation of inhibitory avoidance (IA) memory, while the expression of the transcription factor CCAAT enhancer binding protein β (C/EBPβ) is essential only for the reconsolidation process. Moreover, the critical roles of both protein synthesis and C/EBPβ following IA reactivation are temporally restricted, as they are necessary only for recent but not old IA memories. These results, together with previous findings showing that in the hippocampus both protein synthesis and C/EBPβ expression are required for consolidation but not reconsolidation of IA indicate that the stabilization process that takes place either after training or memory retrieval engages distinct neural circuits. Within these circuits, the C/EBPβ-dependent molecular pathway appears to be differentially recruited.
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U2 - 10.1101/lm.598307
DO - 10.1101/lm.598307
M3 - Article
C2 - 17644752
AN - SCOPUS:34547644831
VL - 14
SP - 504
EP - 511
JO - Learning and Memory
JF - Learning and Memory
SN - 1072-0502
IS - 7
ER -